钯催化异喹啉类化合物的合成

摘要

邻炔苯甲醛首先在醋酸溶剂中与醋酸铵进行脱水缩合反应生成高活性的亚胺中间体，然后该中间体在钯催化剂的催化下进一步发生6-endo-dig关环反应，高产率地生成异喹啉类化合物。另外，该合成方法具有很好的官能团容忍性。%Condensation of α-alkynylbenzaldehyde with ammonium acetate was firstly took place in acetic acid to yield an imine intermediate, which subsequently underwent palladium-catalyzed 6-endo-dig cyclization to afford the isoquinolines in high yield. In addition, a series of functional groups were well tolerated in these transformations.