Objectives A new - type of the activated small molecule compound was constructed by molecular design and synthesis strategy, and the structure activity relationship ( SAR) of the new compound was also investigated . Methods The target compound was synthesized by one - pot reaction of isatin, malononitrile and methyl 3 - aminobut - 2 -enoate in the presence of piperiding. Results The structure was characterized by M. P. , IR, 1H NMR, HRMS and single crystal X — ray diffraction. The crystal of the target compound belongs to monoclinic . Conclusion This paper presented a simple and practical method for synthesis of a new 1,4 — dihydropyridine derivative. The spiro configuration of the product was proved to would be improve the activities of 1,4- DHP.%目的 通过分子设计合成策略构建新型具有活性结构单元的小分子化合物,并对其构效关系进行研究.方法 以氨基巴豆酸甲酯、吲哚满二酮、丙二腈为原料,在哌啶催化下,三组分一锅法合成吲哚螺1,4-二氢吡啶(1,4-DHP)衍生物.结果 化合物的结构通过熔点、红外光谱、核磁共振氢谱和高分辨质谱表征,并通过X射线单晶衍射进一步确定了产物的结构.结论 本实验提供了一种螺环结构1,4-二氢吡啶衍生物的合成方法,方法简单实用,产率较高.构效关系研究表明分子中的螺环结构有利于提高该类化合物钙离子拮抗剂的活性.
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