胃肠道间质瘤临床病理观察

摘要

Objective To explore the diagnosis and differential diagnosis of gastrointestinal stromal tumor (GIST) by studing clinicopathological feature . Methods Immunohistochemistry was used to detect CD 117 , CD34, SMA and S-100, and clinical and pathological features of GIST were analyzed . Results GIST cells were mainly spindle and epithe-lioild cells, some bubble could be seen in the end of and the nucleus in cytoplasm , some showed signet-ring cell, histology structure showed various including sarciniform , diffuse, palisade, nestification and hemangiopericytoma etc . 62 specimen were positive with CD117, 47 specimen were positive with CD34, 30 specimen were positive with SMA , 21 specimen were positive with S-100.Conclusion CD117 and CD34 are specific marker in GIST, SMA and S-100 shows different degrees of expression. It is important to make differential diagnosis with other diseases.%目的 总结胃肠道间质瘤的临床病理特点,探讨其诊断及鉴别诊断.方法 观察62例胃肠道间质瘤的病理形态,采用免疫组织化学S-P法检测CD117、CD34、SMA和S-100,结合临床资料进行分析.结果 间质瘤细胞主要为梭形和上皮细胞样细胞,部分胞质内可见核端空泡或将细胞核推挤到一侧呈印戒细胞样.组织结构呈多样性,可呈束状、弥漫状、栅栏状、巢状或血管外皮瘤样等.62例CD117阳性,47例CD34阳性,30例SMA阳性,21例S-100阳性.结论 CD117及CD34是胃肠道间质瘤较特异的标记物,SMA和S-100在胃肠道间质瘤中有不同程度的表达.胃肠道间质瘤需与多种疾病进行鉴别.