目的：研究不同光疗时间对新生儿高胆红素血症的疗效及不良反应。方法选择120例中等程度新生儿非溶血性高胆红素血症患儿为研究对象，随机分为3组：光疗8 h组，光疗12 h组，光疗24 h组，每组各40例。光疗前、第1次光疗后、治疗后3天分别测血清总胆红素（TSB）及每次光疗后2 h测经皮胆红素（TCB），TCB＜205μmol／L停止光疗，同时记录各组黄疸消退时间及不良反应。结果3组第1次光疗后及治疗3天后，黄疸消退程度及黄疸消退时间差异均无统计学意义（P＞0．05），而光疗的不良反应3组之间差异有统计学意义（P＜0．05），随着光疗时间的延长不良反应增加。结论单次光疗8 h治疗新生儿高胆红素血症即可达到单次光疗12 h和24 h的疗效，而且不良反应少。%Objective To investigate the effects of different phototherapy durations on neonatal hyperbilirubinemia and adverse reactions .Methods A total of 120 newborn infants with moderate to high non -hemolytic hyperbilirubinemia were enrolled in the study .They were randomly divided into three groups according to the duration of phototherapy given :8 hours, 12 hours and 24 hours (n=40 for each).The level of total serum bilirubin (TSB) was measured before photothera-py, after the first phototherapy and three days after treatment .The amount of transcutaneous bilirubin ( TCB) was deter-mined 2 hours after each phototherapy , and phototherapy was continued until TCB <205μmol/L.Meanwhile, the duration that neonatal jaundice appeared in each group and adverse reactions were recorded .Results After the first phototherapy and three days after treatment , no significant difference was found as to the rate and duration that neonatal jaundice ap-peared among these groups (P>0.05).However, these groups were remarkably different in adverse reactions which were increased along phototherapy extended ( P<0.05) .Conclusion Single phototherapy for 8 hours can produce the same ef-ficacy after 12 hours and 24 hours of treatment , with less adverse reactions .
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