原发性卵巢上皮性癌组织中CRM1和胞质p27Kip1表达及其意义

摘要

Objective To investigate the association of CRM1 and cytoplasmic p27Kip1 in epithelial ovarian cancer.Methods The expression of CRM1 and cytoplasmic p27Kip1 in 64 samples of epithelial ovarian cancer tissues were detected by immunohistochemistry.Then,the association between CRM1 and cytoplamic p27Kip1 was discussed.Meanwhile,their association with clinicopathological factors was analyzed.Results Both CRM1 and cytoplamic p27Kip1 were highly expressed in epithelial ovarian cancer tissues,with an expression rate of 76.56% and 64.06%,respectively,which was positively correlated.Meanwhile,CRM1 positive expression was associated with FIGO stage,tumor grade,and lymph node metastases.Cytoplamic p27Kip1 positive expression was associated with FIGO stage and tumor grade.Conclusions High expression of CRM1 may be involved in the progress of epithelial ovarian cancer and is related to poor prognosis.CRM1 positive expression is positively associated with cytoplamic p27Kip1.%目的 探讨染色体区域修复蛋白(CRM1)与细胞质中p27Kip1在原发性卵巢上皮性癌(EOC)组织中表达的相关性及其意义.方法 应用免疫组织化学法分别检测64例原发性卵巢上皮性癌组织中CRM1和胞质p27Kip1的表达,探讨其表达的相关性,分析CRM1与胞质p27Kip1的表达与临床病理特征的关系.结果 CRM1和胞质p27Kip1在卵巢上皮性癌组织中的高表达率分别为76.56%和64.06%,两者呈正相关.同时卵巢癌FIGO分期、肿瘤分级及淋巴结转移情况对CRM1阳性表达有影响.卵巢癌FIGO分期及肿瘤分级对胞质p2727Kip1表达有影响.结论 CRM1高表达可能参与卵巢上皮性癌的进展并与不良预后相关,其表达与胞质p27Kip1呈正相关.