α-硫辛酸对2型糖尿病患者认知功能的影响

摘要

目的 探讨α-硫辛酸对2型糖尿病患者认知功能的影响.方法 2型糖尿病患者140例,按有无应用α-硫辛酸治疗分配在 A 组(70例,糖尿病一般治疗)和 B 组(70例,糖尿病一般治疗基础上每天静脉使用α-硫辛酸)中,使用蒙特利尔认知评估量表(MoCA)分别对2组患者在住院治疗前和治疗结束后30天进行认知功能评估.结果 治疗前,A组患者的认知功能评分平均为23.93±3.45,B组患者的认知功能评分平均为24.90±3.66,2组认知评分的差异无统计学意义(P>0.05);治疗结束后A组患者的认知功能评分平均为22.91±3.74,B组患者的认知功能评分平均26.77±2.27,B组患者的认知功能评分明显高于A组(P<0.05).结论 α-硫辛酸对2型糖尿病患者认知功能有保护作用.%Objective To investigate the effects of α-lipoic acid on the cognitive function of patients with type 2 diabetes mellitus.Methods A total of 140 patients with type 2 diabetes mellitus were divided into two groups, according to their treatment with or without α-lipoic acid.Patients in Group A (n=70) received conventional diabetic therapy, while those in Group B (n=70) were intravenously injected with α-lipoic acid daily in addition to conventional diabetes therapy.Then, the Montreal cognitive assessment (MoCA) was performed to evaluate the cognitive function of these patients before and 30 days after treatment.Results Before treatment, the cognitive function score of Group A was (23.93±3.45) on average, while the average cognitive function score of Group B was (24.90±3.66), which were not significant different between the two groups (P>0.05).After treatment, the cognitive function score of Group A was (22.91±3.74) on average, which was significantly lower than the average cognitive function score of Group B (26.77±2.27).Conclusions α-Lipoic acid has a protective effect on the cognitive function of patients with type 2 diabetes mellitus.