目的 探讨联合检测血清胱抑素C(Cys-C)和C反应蛋白(CRP)水平对评估糖尿病早期肾功能损害的临床价值.方法 87例2型糖尿病(T2DM)患者根据尿微量白蛋白水平分为T2DM组47例和糖尿病肾病(DN)组40例,并选择同期体检健康者40例作为对照组；检测3组研究对象血清Cys-C和CRP水平,并进行比较.结果 T2DM组和DN组患者血清Cys-C和CRP水平显著高于对照组,差异均有统计学意义(P＜0.05)；DN组患者血清Cys-C和CRP水平显著高于T2DM组,差异有统计学意义(P＜0.05).结论 Cys-C和CRP可作为早期评估糖尿病肾损害程度的指标.%Objective To explore the clinical value of serum cystatin C (Cys-C) and C reactive protein (CRP) for evaluating kidney damage in patients with diabetes mellitus. Methods Eighty-seven patients with type 2 diabetes mellitus(T2DM) were divided into T2DM group (n =47) and diabetic nephropathy(DN) group (n =40) according to urine micro-albumin level, while 40 healthy subjects were chosen as control group. The levels of serum Cys-C and CRP were detected and compared among the three groups. Results The levels of serum Cys-C and CRP in T2DM group and DN group were significantly higher than those in control group(P ＜0. 05) ;the levels of serum Cys-C and CRP in DN group were significantly higher than those in T2DM group( P ＜ 0.05). Conclusion Cys-C and CRP can be used as an early index for the degree of kidney damage in assessment of diabetes.
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