碘摄入量与脂代谢的相关研究

摘要

Objective To explore the association between iodine intake level and lipid metabolism in human bodies with normal thyroid function .Methods A total of 1 693 subjects were investigated .Serum thyroid hormones ,urinary iodine concentration and plasma lipid levels were determined in all participants .Accord-ing to different iodine intake levels ,the normal thyroid function participants were classified into three groups :iodine deficiency group (ID group) ,iodine adequate and more than adequate group (IA group) and iodine excess group (IE group) .The study compared lipids (TG ,TC ,HDL-Ch and LDL-Ch) and the ab-normal rate of each lipid indicator in three groups .Correlation between iodine intake level and blood lipids was also studied .Results There were no significant difference of lipid levels (TG , TC , HDL-Ch and LDL-Ch) among three groups (P >0 0.5) .There were no statistical difference of abnormal rate of each lip-id indicator among three groups (P >0 0.5) .There was no correlation between iodine intake level and lipid levels (TG ,TC ,HDL-Ch and LDL-Ch) (P >0 0.5) .Conclusion In normal thyroid function population , there is no difference of lipid levels among different iodine intake and there is no clearly association between iodine intake and lipid levels .%目的：探讨正常甲状腺功能状态下，人群中碘摄入量与血脂水平的关系。方法对新疆乌鲁木齐地区1693成人进行体格检查、问卷调查，并测定平均尿碘中位数、甲状腺功能、甘油三酯（T G ）、总胆固醇（T C ）、高密度脂蛋白胆固醇（HDL-Ch）和低密度脂蛋白胆固醇（LDL-Ch）水平。根据不同碘摄入量分为碘缺乏组、碘充足/超足量组和碘过量组，比较3组血脂水平及血脂异常率。结果3组TG、TC、HDL-Ch和LDL-Ch水平均无统计学差异（P ＞00．5）；3组TG、TC、HDL-Ch和LDL-Ch异常率均无统计学差异（P ＞00．5）。单变量线性回归分析显示：MUI与TG、TC、HDL-Ch和LDL-Ch均无相关性（P ＞00．5）。结论甲状腺功能正常情况下，人群中碘摄入量与血脂水平可能无明确的相关性。