Objective A new evaluation method was used to study the effects of 3 kinds of laxatives in intes-tinal preparation and find out individualized medication suitable for patients′bowel preparation.Methods 450 patients were randomly divided into 3 groups (150 cases in each)undergoing colonoscopy examination. Patients in group A,B and C took 20% mannitol,50% magnesium sulfate and senna respectively.After that the intestinal cleanliness of 3 groups was scored by Boston bowel preparation scale of Medical Center in Boston University (Boston bowel preparation scale,BBPS).The drug tolerance,the diarrhea start time and the frequency of diarrhea were compared and analyzed.Results (1)The 3 groups by BBPS score in the difference of total colon cleansing effect was not statistically significant (P >0.05).(2)The tolerance degree:The difference between group A and group B is statistically significant (P <0.017).Group A were better-tolerated than group B.There was no statistical significance between group A and group C,neither between B and group C (P >0.017).(3)The start time of diarrhea:There was no statistically significant difference between group A and B (P >0.05);the difference between group A and C was statistically sig-nificant (P <0.017);Patients in group C began to have diarrhea after administration later than those in group A.Patients in group C started to have diarrhea later than those in group B,which was statistically significant (P <0.017).(4)The frequency of diarrhea:After taking medicine group B had more frequent diarrhea than group A (P <0.017),which was statistically significant.Group A had diarrhea more fre-quently than group C (P <0.017),group B more frequently than group C (P <0.017),which were statis-tically significant.Conclusion The 3 kinds of laxatives had no difference in bowel preparation effect.20%mannitol was well-tolerated.Diarrhea induced by senna was milder and suitable for long-term diarrhea,the elderly and children.Diarrhea by 50% magnesium sulfate and 20% mannitol was strong and suitable for long-term constipation and temporary bowel preparation before colonoscopy.%目的：探讨3种泻药在电子结肠镜检查前肠道准备中的效果，找出适合患者的个体化肠道准备用药。方法将450例行电子结肠镜检查的患者随机分为3组，每组150例，A 组口服20％甘露醇，B 组口服50％硫酸镁，C 组口服番泻叶。采用 Boston 肠道准备量表（Boston bowel preparation scale，BBPS）对3组患者服药后的肠道清洁度进行评分，比较服药后的耐受性、开始腹泻时间及腹泻次数。结果（1）在耐受性程度上：A 组较 B 组耐受性好，差异有统计学意义（P ＜0．017）；A 组和 C 组、B 组和 C 组差异均无统计学意义（P ＞0．017）。（2）在开始腹泻时间方面：A 组与 B 组比较差别无统计学意义（P ＞0．05）；C 组较 A 组服药后开始出现腹泻的时间晚，差异有统计学意义（P ＜0．017）；C 组较 B 组服药后开始出现腹泻的时间晚，差异有统计学意义（P ＜0．017）。（3）在腹泻次数方面：B 组较 A 组服药后腹泻的次数多，差异有统计学意义（P ＜0．017）；A 组较 C 组服药后腹泻的次数多，差异有统计学意义（P ＜0．017）；B 组较 C 组服药后腹泻的次数多，差异有统计学意义（P ＜0．017）。（4）3组经 BBPS评分后全结肠清洁效果差异无统计学意义（P ＞0．05）。结论3种泻药在肠道准备中清洁效果无差异；20％甘露醇在耐受性方面较好；番泻叶致腹泻作用较温和，适合于长期腹泻、老年患者及小儿。50％硫酸镁和20％甘露醇致腹泻作用较强，适合长期便秘及电子结肠镜检查前临时准备肠道的患者。
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