目的：探讨2型糖尿病（T2DM）患者夜间低氧与血糖的关系及无创通气治疗对2型糖尿病合并睡眠呼吸暂停低通气综合征（OWD）患者昼夜血糖的影响。方法对750例 T2DM 打鼾患者进行夜间脉搏-氧饱和度监测，根据夜间出现低氧情况分为夜间低氧组（484例）与无夜间低氧组（266例），对两组患者年龄、体质指数（BMI）、颈围、腹围、空腹血糖（FBG）进行分析，并对7例 OWD 患者进行睡眠监测、脉搏血氧监测及96 h 动态血糖监测（CGMS），呼吸机无创通气治疗48 h 前后，比较 OWD 患者昼夜血糖变化。结果夜间低氧组和夜间无低氧组 BMI 分别为（27．2±4．8）、（25．5±3．0）kg／m2，颈围分别为（36．7±3．8）、（35．7±3．0）cm，腰围分别为（94．3±11．5）、（89．1±11．1）cm，空腹血糖分别为（6．9±2．4）、（6．5±2．0）mol／L，组间差异均有统计学意义（P ＜0．05）。7例 OWD 患者无创通气治疗前后，昼夜动态动态血糖水平差异有统计学意义（P ＜0．05）。结论T2DM 患者空腹血糖与夜间低氧相关，无创通气治疗可以降低 OWD 患者昼夜血糖水平。%Objective To study the relationship of nocturnal oxygen desaturation and blood sugar level,and the effects noninvasive ventilation(NIV)therapy on the blood sugar level of OWD.Methods 750 snoring patients were received the nocturnal oxygen desaturation test.According the test results,the 750 patients were divided into:the normal and the low nocturnal oxygen desaturation group,to compare the BMI,neck circumference,abdominal circumference and the blood sugar.The blood sugar level were measured and compared before and after the nocturnal NIV therapy.Results The results showed:(1)There were sig-nificant differences between the normal and the low nocturnal oxygen desaturation group on the body mass [(27.2±4.8)kg/m2 vs.(25.5±3.9)kg/m2 ],neck circumference [(36.7±3.8)cm vs.(35.7±3.0)cm],ab-dominal circumference [(94.3±11.5)cm vs.(89.1±11.1)cm]and blood sugar [(6.9±2.4)mmol/L vs. (6.5±2.0)mmol/L]respectively;(2)The blood sugar level of the OWD patient were significantly de-creased after the nocturnal NIV therapy (P <0.05 vs none therapy).Conclusion The nocturnal oxygen desaturation is closely related to the blood sugar level of Type 2 diabetes mellitus patients,and the short-term NIV therapy can reduce the blood sugar level of OWD patients.
展开▼
