EGFR、CTEN和E-cad在非小细胞肺癌中的表达及临床意义

摘要

Objective To explore the expressions and clinical significance of epidermal growth factor receptor (EGFR),COOH-terminus tensin-like molecule (CTEN)and epithelial cadherin (E-cad)in non-small cell lung cancer (NSCLC).Methods The expressions of EGFR,CTEN and E-cad in 36 cases of normal lung tissue and 82 cases of NSCLC tissues were observed with immunohistochemical SP method and their correlation with NSCLC invasion,metastasis and prognosis was analyzed.Results The positive rate of EGFR,CTEN and E-cad was 58.5% (48/82),69.5% (57/82)and 28.1% (23/82)in 82 cases of lung cancer,while 13.9% (5/36),0.0% (0/36)and 100% (36/36)in normal tissues;the differences were all significant (P<0.05).EGFR,CTEN and E-cad expressions in NSCLC tissues were significantly correlated with tumor differentiation,TNM stage and lymph node metastasis (P<0 .0 5 ).The expressions of EGFR and CTEN were correlated with each other in NSCLC (r=0 .5 3 0 , P<0.001),while the expressions of EGFR and CTEN were correlated with that of E-cad (r=0.499,P<0.001;r=0.333,P=0.001 ).Multivariate Cox regression analysis showed that CTEN expression in NSCLC was an independent prognostic factor (P<0.05 ).Conclusion EGFR,CTEN and E-cad may play a role in the development,invasion and metastasis of NSCLC and have some significance in predicting the prognosis of NSCLC.%目的：探讨表皮生长因子受体(EGFR )、CTEN 蛋白(CTEN )和 E-钙粘附蛋白(E-cad )在非小细胞肺癌(NSCLC)中的表达及临床意义。方法采用免疫组化 SP法检测EGFR、CTEN和E-cad在36例正常肺组织和82例NSCLC组织中的表达,并分析其与 NSCLC 的浸润、转移及预后的关系。结果 EGFR,CTEN 和 E-cad在82例肺癌组织中的阳性率分别为58.5%(48/82)、69.5%(57/82)和28.1%(23/82),在正常组织中的阳性表达率分别为13.9%(5/36)、0.0%(0/36)和100%(36/36),差异均有统计学意义(P<0.05)；EGFR、CTEN 和 E-cad 在 NSCLC 组织中的表达与肿瘤分化程度、TNM分期和淋巴结转移显著相关(P<0.05)；NSCLC 中 EGFR 与 CTEN 表达呈相关性(r=0.530,P<0.001),而 E-cad与 EGFR和CTEN表达呈相关性(r=0.499,P<0.001；r=0.333,P=0.001)；多因素Cox回归分析显示,CTEN表达水平可作为 NSCLC预后的独立因素(P<0.05)。结论 EGFR、CTEN 和 E-cad可能在 NSCLC的发展、浸润、转移中起一定的作用；同时对预测 NSCLC的预后具有一定的意义。