In Vitro Dissolution Kinetics of α-TCP Cement Containing Tetracycline Hydrochloride

摘要

In vitro dissolution kinetics of a-tricalcium phosphate (α-TCP) cement andα-TCP cement containing tetracycline Hydrochloride(TTCH) were studied in the present paper.It shows that dissolution process ofα-TCP cement and TTCH-loadedα-TCP cement accords with Avrami dissolution kinetics model: x=1-exp(-kt^n),and Avrami constant n is 0.5 and 0.4 respectively,which means dissolution process is diffusion control.Apparent dissolution activation energy ofα-TCP cement and TTCH-loadedα-TCP cement is about 9.87 kJ/moland 7.17 kJ/mol respectively.Comparing withα-TCP cement,activation energy and Avrami constant of TTCH-loadedα-TCP cement decrease slightly,but its [Ca^(2+)] solubility decreases from 40 ppm to 11.5 ppm, which could result from the change of interfacial property and morphology of hydrated apatite crystal caused by absorption of TTCH on the apatite.