目的:探究妊娠早期甲状腺自身抗体(ATAb)阳性对妊娠期肝内胆汁淤积症(ICP)的诊断意义.方法:选取2016年1月至2016年12月在绍兴市妇幼保健院分娩且孕期检查资料完整的ICP孕妇120例为观察组,等比例随机选取同时期在本院分娩的健康孕妇120例为对照组,分别在妊娠早期及住院分娩时采血测定游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺素(TSH)、甲状腺过氧化物酶抗体(TPOAb)、甲状腺球蛋白抗体(TgAb),统计ATAb阳性者例数,对2组数据进行比较分析.结果:与对照组比,观察组妊娠早期TPOAb明显升高(Z=-2.309,P=0.021),住院分娩时孕周明显偏早(t=-7.318,P<0.001),TSH、TPOAb明显升高(t=3.558,Z=-1.991,P<0.05).结论:妊娠早期ATAb阳性与ICP的发生和发展有一定关系,妊娠早期监测ATAb对于早期发现ICP有一定意义.%objective: To investigate the diagnostic significance of positive antithyroid antibody (ATAb) in the first trimester in intrahepatic cholestasis of pregnancy (ICP). Methods: Select 120 cases of ICP pregnant who delivery in Shaoxing Women and Children's Hospital with complete data from January 2016 to December 2016 as observation group, randomly selecte 120 cases of healthy pregnant according to the same proportion and during the same period as control group. Free triiodothyronine (FT3), free thyroxine (FT4), thyroid stimulating hormone (TSH), thyroid peroxidase antibody (TPOAb), thyroglobulin antibody (TgAb) are respectively deter-mined in both the first trimester and the time of delivery in our hospital. Then statistics the number of positive ATAb cases. Compare and analyze the data of the two groups. Results: The observation group are compared with the control group, TPOAb in the first trimester increased significantly (Z=-2.309, P=0.021), institutional delivery gestational age significantly earlier (t=-7.318, P<0.001), TSH and TPOAb increased significantly (t=3.558, Z=-1.991, P<0.05) Conclusion: There is a certain relationship between positive antithyroid antibody in the first tri-mester and the occurrence and development of ICP. It have a certain significance to monitor thyroid autoantibody in the first trimester for early detection of ICP.
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