AIM: To research and analyze immune function of patients with hepatitis B cirrhosis and patients with alcoholic cirrhosis. METHODS:The data of 93 cirrhotic patients admitted to our hospital from January 2011 to November 2014 were collected and analyzed. According to the type of cirrhosis, patients were divided into observation group 1 with 45 cases of hepatitis B cirrhosis, and observation group 2 with 49 cases of alcoholic cirrhosis. Also 40 health people were selected into control group. Immune indicators, IL⁃2, IL⁃6, and TNF⁃α level in the blood serum, and the level of lymphocyte subsets in peripheral blood were analyzed statistically. RESULTS: Ig levels of hepatitis B cirrhosis and alcoholic cirrhosis were significantly higher than those of the control group, with statistically significant difference (P<0.05), and Ig level of hepatitis B cirrhosis was higher than that of the alcoholic cirrhosis. IL⁃6, and TNF⁃αlevels in serum of the hepatitis B cirrhosis were higher than those of the normal people, and IL⁃2 was lower, with statistically significant difference (P<0.05). Lymphocyte subsets in peripheral blood of hepatitis B cirrhosis, alcoholic cirrhosis were lower than those of the normal people, with statistically significant difference ( P<0.05) . CONCLUSION:The incidence of alcoholic cirrhosis was higher, with poor immune function. Therefore, patients with alcohol ic cirrhosis should be diagnosed and treated early, and in⁃time attention should be given.%目的：分析乙肝肝硬化及酒精性肝硬化患者免疫功能检测结果．方法：收集并分析2011－01／2014－11我院收治的93例肝硬化患者的资料，将其进行整理分组．按照肝硬化的类型分为观察组1和观察组2，观察组1包括乙肝肝硬化患者45例，观察组2包括酒精性肝硬化患者48例．另外选取40名健康志愿者为对照组．对免疫指标、血清中IL⁃2、IL⁃6和TNF⁃α水平、外周血的淋巴细胞亚群的水平进行统计学分析．结果：乙肝肝硬化、酒精性肝硬化的Ig明显高于对照组，差异具有统计学意义（ P＜0．05），乙肝肝硬化的Ig明显高于酒精性肝硬化．乙肝肝硬化患者与正常人相比，血清中IL⁃6、TNF⁃α比较高，而IL⁃2较低，具有统计学意义（P＜0．05）．乙肝肝硬化、酒精性肝硬化与正常人外周血的淋巴细胞亚群相比较低，且具有统计学意义（P＜0．05）．结论：酒精性肝硬化患者的发病率较高，且相对乙肝肝硬化患者的免疫功能较差，所以对酒精性肝硬化患者应该及早发现治疗，并且要对所有的肝硬化患者给予及时的关注．
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