巨噬细胞参与骨骼肌再生机制的研究进展

摘要

In recent years, many researches have demonstrated that macrophages play a vital role in organ or tissue regeneration. Macrophages are necessary for skeletal muscle regeneration after injury. The recruitment of circulating mono-cytes/macrophages was mediated through myogenic cells and muscle resident macrophages. Macrophages are involved in both phases of skeletal muscle regeneration: first, swallowing necrotic myo-fibers, then the phenotype of macrophages switched from pro-inflammatory to anti-inflammatory. Second, factors secreted by anti-inflammatory macrophages improved the differentiation of myogenic cells and resulted in regeneration of skeletal muscle.%近年来，越来越多的研究证实，巨噬细胞在人体多种组织器官再生过程中发挥重要作用。在骨骼肌再生过程中，巨噬细胞的参与是必需的。骨骼肌受损后，成肌细胞与固有巨噬细胞募集循环系统中的单核/巨噬细胞；浸润的巨噬细胞吞噬凋亡或坏死的肌纤维后，从致炎的表型转变为抗炎表型；抗炎巨噬细胞分泌的因子促进了成肌细胞的分化和融合，从而介导了骨骼肌的再生。