癌胚抗原相关细胞黏附分子6在胆管癌中的表达及其意义

摘要

Objective:To detect the level of CEACAM6 in the bile of patients with biliary cancer and to explore its diagnostic value for cholangiocarcinoma.Methods:Sixty-three patients were enrolled in this study and were divided into cholangiocarcinoma group (n=32) and benign group (n=31).Bile was collected during operation.The concentration of CEACAM6 was quantified by ELISA and correlated with pathologic diagnosis.Diagnostic capability of CEACAM6 was evaluated by Wilcoxon rank-sum,linear regression,multiple regression,and receiver operating characteristic (ROC) curve analysis.Results:Patients in the benign group were younger,predominantly female,and had lower median biliary CEACAM6 levels than patients in the cholangiocarcinoma group (8.5 ng/mL vs 39 ng/mL,P≤0.001).ROC curve analysis determined CEACAM6 to be a positive predictor and a CEACAM6 level ＞14 ng/mL was associated with 87.5％ sensitivity,and 69.1％ specificity.Multiple regression analysis suggested elevated alkaline phosphatase and the presence of biliary endoprostheses may influence CEACAM6 levels.Conclusion:Biliary CEACAM6 level may increase in patients with cholangiocarcinoma and can identify cholangiocarcinoma.%目的:检测胆管癌患者胆汁中癌胚抗原相关细胞黏附分子6(CEACAM6)的水平并判断其对胆管癌的诊断价值.方法:选取因胆管梗阻行手术治疗的患者63例,根据术后病理结果分为良性组(n=32)和胆管癌组(n=31).于术中留取患者胆汁,应用ELISA法测定CEACAM6水平.应用Wilcoxon Rank Sum、线性回归、多元回归以及受试者工作特征曲线(ROC)评估CEACAM6对胆管癌的诊断价值.结果:与胆管癌组相比,良性组患者年龄更小,女性比例更高,CEACAM6水平更低(8.5 ng/mLvs39 ng/mL,P≤0.001).ROC曲线显示,当CEACAM6水平大于14 ng/mL时,其诊断胆管癌的敏感性为87.5％,特异性为69.1％.多元回归分析显示,碱性磷酸酶和支架数与CEACAM6相关.结论:胆管癌患者CEACAM6水平升高,可作为胆管癌的诊断指标.