The string with multi-packer, which is recommended by Norsok D010 standard, is an important type of high tem-perature high-pressure completion string. However, compared with the single packer, the force and deformation of completion string with multi-packer are more complicated, and the local trap pressure does great damage to pipe string. Therefore, the mechanical model with consideration of the end effect, deformation effect and effect of thermal expansion and contraction as well as helical and sinusoidal buckling effect was established. Besides, calculation based on field condition was performed. The results indicate that the force and deformation of string are greatly affected by the packer depth and wellhead temperature and pressure, and effect of multi-packer on mechanical behavior of string should be considered in the string design and evaluation.%带多封隔器的完井管柱是Norsok D010规范推荐的高温高压气井完井管柱中的重要类型，但是多封隔器完井管柱结构在井下工况中的受力和变形较单一结构管柱更为复杂，并且多封隔器之间局部的圈闭压力可能导致管柱损坏。为此，针对多封隔器管柱结构特点，建立了考虑端面效应、热胀冷缩效应、形变效应、螺旋和正弦屈曲效应影响的管柱变形和受力计算模型，并结合现场实际工况开展了实例计算。计算结果表明，封隔器在井筒中的位置以及井筒温度压力对整个管柱的受力和变形影响较大，在多封隔器复合管柱设计和安全评价时需要考虑多封隔器对管柱力学行为的影响。
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