c-met蛋白与食管鳞状细胞癌的临床分期及细胞分化程度的相关性

摘要

Objective To explore the correlation of c-met protein with the clinical staging and cell differentiation of esophageal squamous cell carcinoma (ESCC). Methods A total of 100 patients with ESCC were enrolled were examined for expression of c-met protein using immunohistochemistry, and the patients in negative and positive c-met expression groups were compared for clinicopathological characteristics and overall survival. Results The 100 ESCC patients included 67 male and 33 female patients with a median age of 59 years;49 of the patients were negative and 51 were positive for c-met expression. Positive c-met expression was significantly correlated with advanced TMN stages and lower tumor differentiation. Kaplan-Meier survival curve showed that the median survival time of c-met-positive patients was significantly reduced compared with that of c-met-negative patients (30.9 vs 48.2 months, P<0.05). COX regression analysis showed that c-met was a independent risk factor for the overall survival of the patients (HR:2.34, 95%CI:1.63-4.54, P<0.05). Conclusion A positive expression of c-met protein is significantly correlated with an advanced TMN stage, lower tumor differentiation and a poor prognosis, and may serve as a indicator for predicting the prognosis of ESCC.%目的：探讨c-met蛋白与食管鳞癌病人临床分期及细胞分化程度的相关性。方法选择于本院就诊的食管鳞癌患者100例，采用免疫组织化学检测食管癌组织中c-met蛋白的表达情况，根据c-met蛋白的平均表达水平将食管癌患者分为c-met阴性组（c-met蛋白不表达）和c-met阳性组（c-met蛋白有表达），并对这两组病人的临床病理特征、总生存时间进行比较。结果对100名食管鳞癌患者（男67例，女33例，平均年龄为59岁）的实验结果进行分析。c-met蛋白表达阴性组51例，c-met蛋白表达阳性组49例。c-met蛋白表达阳性者较c-met蛋白表达阴性者的临床分期更高，分化程度更低。Kaplan-Meier生存函数曲线表明，阳性组患者生存率较低值组显著降低c-met蛋白表达阴性组中位生存时间为48.2月，蛋白表达阳性组为30.9月，差异具有统计学意义（P<0.05）。COX回归分析表明，c-met过表达是食管鳞癌患者总生存的独立不良预后因素（HR：2.34，95%CI：1.63~4.54，P<0.05）。结论 c-met蛋白在食管鳞癌组织中的表达与食管癌的分期和分化程度密切相关，并且可能是患者随访期间生存时间的独立预测因子。