目的：：探讨中国人载脂蛋白E基因多态性与轻度认知功能损害( mild cognitive impairment, MCI)的相关性。方法：检索已发表的中国人载脂蛋白E基因多态性与轻度认知功能损害的相关病例对照研究,选择符合条件的文献进行Meta分析。采用RevMan 5.2统计软件进行数据处理。采用漏斗图评价入选文献的发表偏倚。结果：共入选9篇符合条件的文献纳入Meta分析。分析结果显示,携带ε2/2、ε3/3、ε4/4、ε2/3、ε2/3、ε3/4的个体发生轻度认知功能损害的 OR 值为0.97(95%CI 0.31~3.02)、0.43(95%CI 0.34~0.55)、2.68(95%CI 1.42~5.06)、0.67(95%CI 0.47~0.96)、2.51(95%CI 1.61~3.91)、2.40(95%CI 1.80~3.21)。携带ε4、ε3、ε2的个体OR值为2.68(95%CI 2.14~3.35)、0.46(95%CI 0.38~0.56)、1.12(95%CI 0.87~1.44)。结论：ε4是轻度认知功能损害的遗传易感基因,ε3可能是保护基因。同时, ApoEε4/4、ApoEε2/4和ApoEε3/4基因型是MCI的危险因素,ApoEε3/3与ApoEε2/3基因型是MCI的保护因素。%Objective:To study the relationship between apolipoproteion E gene polymorphism and mild cognitive impairment( MCI) in Chinese population. Methods: The literatures with ApoE polymorphism and mild cognitive impairment concerning Chinese population were reviewed. The selected literatures were analyzed by Meta analysis. The software RevMan 5. 2 was used for Meta analysis and publication bias was tested by funnel plot. Results:Nine papers were selected based on the criteria. Meta analysis results showed that the combined OR values of mild cognitive impairment for subjects of ε2/2 ,ε3/3 ,ε4/4 ,ε2/3 ,ε2/3 ,ε3/4 were 0 . 97 ( 95%CI 0 . 31 -3 . 02 ) ,0 . 43 (95%CI 0. 34-0. 55),2. 68(95%CI 1. 42-5. 06),0. 67(95%CI 0. 47-0. 96),2. 51(95%CI 1. 61-3. 91), 2. 40(95%CI 1. 80 -3. 21),respectively. The pooled OR values of mild cognitive impairment forε4,ε3 andε2 carriers were 2 . 68 ( 95% CI 2 . 14 -3 . 35 ) , 0 . 46 ( 95% CI 0 . 38 -0 . 56 ) , 1 . 12 ( 95% CI 0 . 87 -1 . 44 ) , respectively. Conclusions:The ApoEε4 carriers might be a risk factor andε3 carrers be a protective factor for mild cognitive impairment. Meanwhile ApoE ε4/4, ApoE ε2/4 and ApoE ε3/4 genotypes increase and ApoE ε3/3, ApoE ε2/3 genotype decrease the risk of MCI.
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