非小细胞肺癌患者EGFR突变与PET/CT 18 F-FDG摄取之间的相关性

摘要

Objective:To evaluate the relationship between the presence of epidermal growth factor receptor ( EG-FR) mutations and 18-fluoro-2-deoxyglucose ( 18 F-FDG) uptake of primary tumor in patients with non-small cell lung cancer (NSCLC).Methods: Totally 126 patients with NSCLC diagnosed by pathology were collected , who underwent PET/CT examinations and EGFR mutation tests before any anti-tumor therapies , the relationship between the maximum standard uptake value ( SUVmax) and the EGFR mutation was analyzed .Results:EGFR mutations within exons 19 and 21 were detected in 51 NSCLC patients (40.5％), the SUVmax was significantly lower in EGFR mutant-type than wild-type (6 ±4 vs 11 ±6, P=0.014).For the prediction of EGFR mutations by SUV max, the area under the receiver operating characteristic curve (AUC) was 0.769, P=0.001.When the cut off value was 8.15, the Youden index reached the maximum value 0.455.Conclusion:18 F-FDG uptake is associated with the presence of EGFR mutation , patients with lower SUV max are more likely to harbor EGFR mutations .%目的:研究非小细胞肺癌组织表皮生长因子受体(EGFR)突变情况与肿瘤组织18 F-脱氧葡萄糖(18 F-FDG)摄取的关系.方法:回顾性分析经病理证实的126例非小细胞肺癌患者的临床资料,于治疗前行18 F-FDG PET/CT检查及EGFR基因突变检测,分析FDG最大标准摄取值(SUVmax)与EGFR突变之间的关系.结果:本组病例中有51例患者(40.5％)19及21外显子突变,突变型患者原发灶的SUVmax低于野生型患者(6±4 vs 11±6,P=0.014),用SUVmax预测EGFR突变时,受试者工作特征曲线(ROC曲线)下面积是0.769,P=0.001;当SUVmax取界值8.15时,约登指数最大为0.455.结论:非小细胞肺癌原发灶18 F-FDG摄取与EGFR突变存在相关性,EGFR突变更易发生在低SUVmax患者.