Objective To evaluate the variations of intraocular pressure (IOP) in suspected open-angle glaucoma (OAG) patients. Methods The variations of IOP were measured in 216 eyes of suspected OAG patients at 4-hour intervals for 48 h. Based on the results of the serial IOP measurements, optic disc changed and visual field defected, the patients were diagnosed as primary OAG (POAG), normal tension glaucoma (NTG), ocular hypertension (OHT), or physiologic cup (PC). Results After the serial IOP measurements, 16.7% of the suspected OAG patients were diagnosed as POAG, 32.4% as NTG, 24.5% as OHT, and 26.4% as PC. The highest percentages of the POAG group had peak IOP at 8 AM (19.4%) and their trough IOP at 10 PM (27.8%); the NTG group had peak IOP at 12 AM (18.6%) and their trough IOP at 12 PM (22.9%); the OHT group had peak IOP at 4 AM (22.6%) and their trough IOP at 10 PM (26.4%); and the PC group had peak IOP at 4 AM (21.1%) and their trough IOP at 12 PM (21.1%). The percentages of peak IOP outside clinic (8 AM-4 PM) in the POAG, NTG, OHT and PC groups were 55.6%, 50.0%, 58.4% and 45.7%, respectively. The mean magnitude of variance was 5.1-6.7 mmHg in those suspected OAG patients. There was a strong positive correlation in IOP between both eyes at each time point of measurement and the variation curves of the right and left eyes had parallel profiles in those suspected OAG patients. Conclusion Serial measurement of IOP is still needed, in order not to miss the peak and the trough IOP readings in suspected OAG patients, which helps in better management of glaucoma.
展开▼
