FORMATION OF SOLID PARTICLES IN BLOOD STREAM AND EFFECTS ON PULMONARY ULTRASTRUCTURE DURING CARDIOPULMONARY BYPASS IN CHILDREN

摘要

An electronic particle size analyzer (Coulter Counter ZM) was utilized to quantitate the particulate microemboli, varying from 15 to 80μin size, during cardiopulmonary bypass. We confirmed the main causes of microemboli were banked blood, cardiotomy reservoirs and oxygenators. Electronic microscopic examination showed that a large number of solid particles more than 20μin size were formed during heart-lung bypass, which obstructed microcirculation and damaged the pulmonary capillary endothelial and alveolar epithelial cells. The degree of histological damage was related to the number and size of microemboli and time of pulmonary microcirculatory obstruction.