Obiective To measure coronary flow reserve (CFR) with angiography and computer-ass assisted technique in patients with left ventricular hypertrophy due to hypertension. Methods Coronary arterialdiameter, cross - sectional area and blood velocity of coronary flow in left anterior descending artery (LAD) andright coronary artery (RCA) were calculated with a computer in serial images of coronary angiography. Coronaryflow reserve was then measured in 22 patients with left ventricular hypertrophy due to hypertension (hypertropygroup) and 26 normal subjects (control group). Results Blood velocity and flow of both coronary arteries weresignificantly higher in hypertrophy group (LAD: n=22, RCA: n=14) than in control group (LAD: n=26, RCA:n=20) before intracoronary papaverine. However, blood velocity and flow of both coronary arteries were increasedsimilarly in both groups after intracoronary papaverine. Coronary flow reserve in hypertrophy group (LAD:CFR=2.2± 1.0, RCA： CFR= 2.9± 0.8) was significantly lower than in control group (LAD: CFR= 3.9± 2.1, RCA:CFR=5.5±2.0, all P<0.01). Conclusion The study indicates that coronary flow reserve is reduced in patientswith left ventricular hypertrophy due to hypertension which may be related to a higher coronary flow at restingstate.
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