Objective: To investigate the effect of indomethacin-Cu-IUD on the endometrium. Methods: Four kinds of IUDs were inserted into the uteri of rats and rabbits through laparotomy. The animals were killed at 1,3,6 months after treatment and their uteri were taken for histological examination with either microscopy and transmission electron microscopy. The rats and rabbits without IUD served as control. Results: There was no obvious pathological change in indomethacin-Cu-IUD group at 1-6 months after insertion of IUD, similar to the control. There were some mild edema and hyperplasia of fibrous tissues in endometrium in Cu-IUD group. There was a significantly change in the vessels of microcirculation. Most vessels were normal or contracted in the indomethacin--Cu--IUD group (75 % ) and control group(87% ), while most vessels were dilated in the Cu-IUD group(70% ) (P<0. 01 ). Conclusion: Indomethacin--Cu-IUD has no harmful effect on endometrium.
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