两次移植提高反复体外受精-胚胎移植失败患者的妊娠率的研究

摘要

在体外受精-胚胎移植(IVF-ET)中,妊娠率通常在40％～50％左右,对于首次进行IVF-ET治疗的患者成功率可达60％[1],但仍有部分患者在多次IVF-ET后仍然失败,此部分患者再次行IVF的成功率低于总体的成功率,失败的原因可能是多方面的,如胚胎因素、内膜因素、卵巢反应因素、免疫因素等.如何提高此部分患者的临床妊娠率是辅助生殖医学工作者面临的挑战.Machtinger等[2]报道对反复失败的患者采用两次移植方法,可提高妊娠率.我们针对反复失败患者采用此方法,提高了其临床妊娠率,现报道如下.%Objective: To compare IVF outcome following double transfer with that following one transfer among patients with previous multiple IVF failures.Methods: 60 patients with previous more than 2 times IVF failures and with more than 2 available embryos were randomize divided into 2 groups: The study group underwent double transfer of 1 of day 3 embryo and 1-2 of D5 embryos. The control group underwent embryo transfer on day 3 only.Results: Double transfer resulted in a pregnancy rate of 53. 3% (16/30) , implantation rate of 19. 77% (17/86) compared with 23. 3%(7/30) and 7. 95%(7/88) following day 3 transfer (P<0. 05).Conclusion: Double transfer of embryos may be indicated for repeated IVF failure patients with more than 2 available embryos.