多囊卵巢综合征异常的内分泌激素改变对子宫内膜的影响

摘要

多囊卵巢综合征(PCOS)是导致育龄期妇女不育及代谢异常的最常见内分泌疾病之一.PCOS患者的临床及生化表型各异,其最主要的临床表现包括稀发排卵/闭经及高雄激素表现(痤疮、多毛或高雄激素血症),且自然流产率及诱发排卵后的胚胎种植失败率均高于正常人,这些明显与PCOS子宫内膜本身异常相关,而不能仅归咎于其排卵障碍.本文对PCOS异常的内分泌激素改变对子宫内膜的影响作一综述.%Polycystic ovary syndrome(PCOS) is the most common endocrine disease associated with infertility and metabolic abnormality in women of child-bearing age.The clinical and biochemical features vary among individuals.The most widely accepted clinical characteristics of PCOS are oligo-ovulation or anovulation and hyperandrogenism.PCOS patients have a higher implantation failure rate after induction of ovulation,and they are more likely to suffer from spontaneous abortion.The infertility of PCOS patients should be attributed not only to ovulation disorders but also to endometrial dysfunction.Here we review the features of the endometrial abnormalities in women with PCOS.