EZH2与哺乳动物生殖研究新进展

摘要

组蛋白甲基化转移酶同源序列增强子(enhancer of zeste homolog,EZH)是由EZH基因编码的一种组蛋白赖氨酸甲基化转移酶,有EZH1和EZH2两种亚型,属于多梳家族(Polycomb Group,PcG)蛋白成员.PcG家族的成员相互结合形成多聚蛋白复合物参与基因转录调控、DNA甲基化,促进异染色质的形成从而发挥沉默基因的功能、维持胚胎细胞的正常增殖与分化.本文主要介绍EZH2的基本功能及其在哺乳动物生殖和相关疾病中的研究新进展.%EZH (enhancer of zeste homolog)is a EZH gene-encoded histone lysine methyltransferase,belonging to the polycomb group(PcG)members,with two kinds of proteins-EZH1 and EZH2.The members of the PcG family protein are involved in gene transcription and DNA methylation,promoting the formation of heterochromatin to play a silent gene function,maintaining normal proliferation and differentiation of embryonic cells.This paper describes the basic functions of EZH2 and its new advances in early mammalian reproduction and related diseases.