普通外科584例患者围手术期抗生素应用分析

摘要

Objective:To evaluate the perioperative prophylactic application of antibiotics in our hospital. Methods Antibiotics evaluation medical records of 584 general surgical patients in our hospital in 2011 were analyzed retrospectively in respect of selection of antibiotics, medication time, treatment course, drug combination and drug expenditure, etc. Results Among 584 patients, perioperative prophylactic application of antibiotics accounted for 98.96% (578 cases) with 698 drug times totally. The frequency of antibiotics use was 1. 20 times. 240 cases(41. 96% ) received antibiotics 2 hours before operation. Mean medication duration was (7. 02 ±3. 23) days. 10 categories and 35 kinds of antibiotics were used in perioperative period. The top 3 drugs for type I and II incision operation were the first-generation and second-generation cephalosporins and cephamycins. Antimicrobial agents were mainly single use, two associated medication only 48 cases (8.28% ) , and no triple therapy. The adverse reaction rate was 3.01% (21/698). Conclusion The results show that irrational use of perioperative prophylactic antibiotics is common in general surgery, and it must be standardized with relevant measures.%目的 评价我院普通外科围手术期患者预防用抗生素情况.方法 对我院2011年584例外科患者抗生素专项点评病例资料进行回顾性总结分析,从抗生素品种选择、用药时机、疗程、联合用药、费用等指标进行分析比较.结果 在584例Ⅰ～Ⅲ类切口手术患者中,抗生素预防性用药为578例(98.97％),累计用药698次,平均每例应用1.20次.术前2h给药者240例(41.96％),用药时间(7.02±3.23)d,所用药物涉及10大类35种,第1、2代头孢菌素,头霉素在Ⅰ、Ⅱ类切口手术中列前3位.抗生素主要为单用,二联用药48例(8.28％),无三联用药.不良反应发生率为3.01％ (21/698).结论 我院普通外科手术围手术期患者预防用抗生素仍存在一定不规范,需进一步采取相关措施加以干预.