检测妊娠期GD子代血清TRAb的临床价值

摘要

Objective To investigate the relationship between thyroid function and serum TRAb level of neonatus homed by puerperas who have Graves disease. Methods To detect the serum levels of FT3, FT4, sTSH ( with RIA ) and TRAb ( with ECLLA ) in 126 neonatus horned by puerperas who had Graves disease and 40 neonatus borned by healthy puerperas. Results The incidence of thyroid dysfunction was 25.4% ( 32/126 ) in 126 neonatus bomed by puerperas who had Graves' disease. Among them, the increase of serum TRAb occupied 1.59% ( 2/126 ), the incidence of hypothyroidism made up 23.81% ( 30/126 ), the ratio of neonatus who had normal serum TRAb was 98.41% ( 124/126 ), the ratio of neonatus who had normal thyroid function Ab was 74.60% ( 94/126 ).The serum levels of FT3, FT4, sTSH and TRAb in 40 neonatus bomed by healthy puerperas were normal. Conclusion It has important clinical value by detecting the sernm TRAb level of neonatus borned by puerperas who have Graves' disease to diagnose diseases of thyroid gland in neonatus, especially only one Graves' disease.%目的:探讨母妊娠合并Graves'病的新生儿血清促甲状腺激素受体抗体(TRAb)水平与甲状腺功能关系.方法:采用放射免疫分析(RIA)检测126例妊娠合并Graves'病(毒性弥漫性甲状腺肿)产妇新生儿和40例健康产妇新生儿的FT3、FT4、超敏促甲状腺激素(sTSH),采用电化学发光免疫分析(ECLIA)检测TRAb水平.结果:母妊娠合并Graves'病的126例新生儿中,新生儿甲状腺功能异常发生率为25.4%(32/126),其中血清TRAb水平升高发生率为1.59%(2/126),甲状腺功能减退发生率为23.81%(30/126).血清TRAb水平正常为98.41%(124/126),其中甲状腺功能正常发生率为74.60%(94/126).40例健康产妇新生儿的FT3、FT4、sTSH、TRAb均正常.结论:检测母妊娠合并Graves'病产妇的新生儿血清TRAb水平在新生儿甲状腺疾病特别是Graves'病的诊断中具有重要的临床价值.