Objective To evaluate the clinical significance of determination of changes of serum CA125, CA19-9, CEA and SA levels after operation in patients with ovarian cancer. Methods Serum CA125, GA19-9, CEA ( with RIA ), serum SA ( with chemistry )levels were determined in 32 patients with ovarian eancer both before and after operation as well as in 35 controls. Results Before operation the serum CA125, GA19-9, CEA and SA levels were significantly higher in the patients than those in controls ( P ＜0.01 ), 6 months after operation, the levels were not obviously different from those in controls ( P ＞ 0.05 ). Conclusion Detecting the serum CA125, CA19-9, CEA and SA levels after operation might be of prognostic importance in patients with ovarian cancer.%目的:探讨了卵巢癌患者手术治疗前后血清CA125、CA19-9、CEA和SA检测的变化及临床意义.方法:应用放射免疫分析和化学法对32例卵巢癌患者进行了手术治疗前后血清CA125、CA19-9、CEA和SA检测,并与35名正常人作比较.结果:卵巢癌患者在治疗前血清CA125、CA19-9、CEA和SA水平非常显著地高于正常人组(P＜0.01).手术治疗6个月后则与正常人组比较无显著性差异(P＞0.05).结论:检测卵巢癌患者血清CA125、CA19-9、CEA和SA水平的变化对了解病情、观察疗效和预后判断均有重要的临床价值.
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