Objective Explore type 2 diabetes mellitus ( DM2 ) and complicating with kidney disease patients homocysteine (Hcy ), adipanectin ( APN ), vascular endothelial growth factor ( VEGF ) and urine albumin change relations. Methods A normal controls and no complications of diabetes groups, conbined with nephropathy. A comparison were measured of serum APN, plasma VEGF, Hcy and urine albumin level among. Results Two groups of patients with diabetes fasting blood glucose level were no significant difference. Also there is no difference of BUN and Cr in three groups urine albumin in diabetic-nephropathy albumin increased significantly ( P ＜ 0.01 ), than without complications group. Three goups of Hcy concentrations were significantly higher than that of normal control group ( P ＜ 0.01 ), serum APN, plasma VEGF level obviously lower than normal control group, which increased in patients with nephropathy increased or reduced more apparently no complications group also have obvious difference ( P ＜0.01 ). Conclusion In patients with diabetes in two groups, plasma Hcy and urine albumin were significantly higher APN, and VEGF decreased significantly. In patients with nephropathy manifested more apparently, but renal damage did not enter decompensated period, clinically necessary for people with diabetes testing serum APN, plasma VEGF, Hey and mine Albumin level, promptly intervention to lrevent or relieve the further development of diabetes.%目的:探讨2型糖尿病(DM2)及合并肾病患者同型半胱氨酸(Hcy)、脂联素(APN)、血管内皮生长因子(VEGF)及尿Alb的变化关系.方法:设正常对照组、无并发症糖尿病组、合并肾病组三组,比较三组间血清APN、血浆VEGF、Hcy及尿Alb的水平.结果:两组糖尿病患者间空腹血糖水平无显著差异;BUN和Cr在三组间无差异,但糖尿病合并肾病(DN)患者尿Alb较无并发症组明显升高(P＜0.01),糖尿病各组血浆Hcy浓度均明显高于正常对照组(P均＜0.01),血清APN、血浆VEGF的水平明显低于正常对照组,其中合并肾病患者增高或降低更为明显,与无并发症组亦有明显差异(P＜0.01).结论:在两组糖尿病患者中血浆Hcy、尿Alb均明显增高且血清APN、血浆VEGF明显降低,且在有肾病合并症的患者中差异更加明显,但肾功能损伤并未进入失代偿期,在临床上有必要对糖尿病患者检测血清APN、血浆VEGF、Hcy及尿Alb的水平,及时进行干预治疗,从而预防或缓解糖尿病的进一步发展.
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