ACI患者血清IGF-Ⅱ、IL-8和TNF-α水平的变化及临床意义

摘要

Objective To explore the clinical significance of changes on serum ICF- Ⅱ ,IL-8 and TNF-α levels in patients with a-cute cerebral infaction. Methods Serum IGF-Ⅱ ,IL-S and TNF-α levels were determined with radioimmunoassay(RIA)in 33 patients with acute cerebral infarction and 35 normal controls. ReslutS The serum IGF- Ⅱ ,IL-8 and TNF-α in patients with acute cerebral infarction were significantly higher than those in controls (P<0.01) , the serum IGF- Ⅱ levels were positive correlation with serum IL-8, TNF-a levels (r =0.5712, 0.6018, P<0.01 ). Conclusion Detection of changes of serum IGF- Ⅱ, IL-8and TNF-α levels can be help to assess the progress and prognosis of the disease, also such laboratory items offer to realise the pathosis and therapeutic effect possess definite clinical value.%目的:探讨急性脑梗死(ACI)患者血清IGF-Ⅱ、IL-8和TNF-α水平的变化及临床意义.方法:采用放射免疫分析对33例ACI患者进行了血清IGF-Ⅱ、IL-2和TNF-α检测,并与35名正常健康人作比较.结果:ACI患者血清IGF-Ⅱ、IL-2和TNF-α水平均非常显著地高于正常人组(P＜0.01),且血清IGF-Ⅱ水平与IL-8和TNF-α水平呈正相关(r=0.5712、0.6018,P＜0.01).结论:检测ACI患者血清IGF-Ⅱ、IL-2和TNF-α水平变化,对观察疾病的预后和疗效具有确切的临床价值.