COPD患者血清IL-6、IL-8、hs-CRP和IL-18检测的临床意义

摘要

目的:观察慢性阻塞性肺疾病(COPD)患者治疗前后血清IL-6、IL-8、hs-CRP和IL-18水平的变化及临床意义.方法:应用放射免疫分析和免疫比浊法对32例COPD患者进行了治疗前后血清IL-6、IL-8、hs-CRP和IL-8检测,并与35名正常健康人作比较.结果:COPD患者在治疗前血清IL-6、IL-8、hs-CRP和IL-18水平均非常显著地高于正常人组(P＜0.01),经中西医结合治疗1个月后与正常人组比较仍有差异(P＜0.05).结论:IL-6、IL-8、hs-CRP和IL-18的测定,可适用为一种筛选方法,其变化可能以不同的方式参与了COPD的发病,此外,该些项目的检测对了解病情、指导治疗具有重要的临床价值.%Objective To observe the clinical significance of changes on serum IL-6, IL-8, hs-CRP and BL-18 levels after treatment in patients with COPD. Methods Serum 11-6, IL-8 (with RIA) , serum hs-CRP(with immunotubidimetry) levels were measured both before and after treatment in 32 patients with COPD as well as in 35 normal controls. Results Before treatment, the serum IL-6, IL-8, hs-CRP, IL-18 levels were significantly higher than those in controls (P < 0.01). After 1 month of treatment the serum IL-6, IL-8, hs-CRP and IL-18 dropped markedly but remained higher difference than those in controls ( P < 0.05 ). Conclusion Measurement of serum IL-6,IL-8,hs-CRP and IL-18 were suitable to be used as a screening method. Besides, it could take part in pathogenesis of COPD in various ways and the changes of these items levels is of important values to realize pathosis and therapeutic effect.