脑出血患者血浆高迁移率族蛋白B1浓度的检测及临床意义

摘要

目的:揭示脑出血患者血浆高迁移率族蛋白B1浓度的变化,探讨其对预后的预测价值.方法:收集高血压性基底节区出血患者作为脑出血组,共98例.收集同期健康体检人群作为对照组,共40例.脑出血组静脉血在入院时获得.对照组静脉血体检时获得.ELISA检测血浆高迁移率族蛋白B1浓度.统计分析其与患者预后的相关性.结果:脑出血后1个月内死亡29例(29.6%).t检验显示,脑出血组血浆高迁移率族蛋白B1浓度(7.6±2.7)ng/ml显著高于对照组(1.3±0.4)ng/ml(p 7.9 ng/ml predicted 1 -month mortality of patients with 86.2% sensitivity and 79.7% specificity ( Area under curve = 0.823 , 95% CI =0.759 ~0.892, P <0.001) .Conclusion Increased high mobility group box 1 protein level is found after intracerebral hemorrhage in association with a poor clinical outcome.Such a laboratory marker maybe helpful to judge the prognosis of these patients at early stage.