Objective To explore the effect of repetitive transcranial magnetic stimulation ( rTMS) on sensory gating P50 deficit in schizophrenia patients that characterized with negative symptoms .Methods 30 schizophrenia patients with predominant negative symptoms and received risperidone treatment were randomly divided into two groups-real rTMS treatment group ( research group , n =15 ) and sham rTMS treatment group (control group, n=15).Each patient in the research group received 20 rTMS sessions over 4weeks that delivered theta burst stimulation ( TBS ) to the left dorsolateral prefrontal cortex .All patients fulfilled the evaluation of sensory gating (SG) P50 with the conditioning (S1)-testing (S2) paradigm before rTMS treatment and 4 weeks after treatment.Efficacy was evaluated blindly using the Scale for the Assessment of Negative Symptoms (SANS). Results 4 weeks after treatment , the SANS scores were reduced remarkably than those before treatment in both two group, and the scores in research group was lower than that in control group (P<0.001).There was no significant difference in P50 parameters between the two groups before treatment ( P >0.05).No significant difference was found in S 1 latency and amplitude between the two groups after treatment .The S2 amplitude and latency, the S2/S1 ratio and percentage of abnormal P50 in research group were lower than control (P<0.05). Conclusions rTMS combined with medicine treatment could improve the negative symptoms and the deficit in SG P50 nhibition of schizophrenia .%目的：探讨重复经颅磁刺激（ rTMS）对以阴性症状为主的精神分裂症患者感觉门控P50缺陷的影响。方法30例以阴性症状为主的、采用利培酮治疗的精神分裂症患者随机分为rTMS真刺激组（研究组，15例）及rTMS伪刺激组（对照组，15例），分别接受20次rTMS治疗。治疗开始及疗程结束时测定P50，P50实验模式为听觉条件刺激（S1）测试刺激（S2）模式。并应用阴性症状量表（SANS）评定疗效。结果两组治疗后SANS评分均低于治疗前（P＜0．001），且治疗后研究组评分低于对照组（P＜0．001）。治疗前P50测量指标在两组患者之间差异均无统计学意义（P＞0．05），治疗前后比较，两组S1潜伏期和波幅未发现明显差异（P＞0．05），研究组S2潜伏期和波幅较治疗前和对照组缩短和降低（P＜0．05），S2/S1比值和P50异常比率较对照组明显降低（P＜0．05）。结论 rTMS结合药物治疗可以改善精神分裂症患者的阴性症状，同时改善精神分裂症的感觉门控P50抑制缺陷。
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