糖耐量正常的2型糖尿病一级亲属肠促胰岛素分泌与胰岛β细胞功能的研究

摘要

目的：探讨年轻的糖耐量正常的2型糖尿病一级亲属肠促胰岛素分泌、胰岛β细胞功能的改变。方法正常对照组( NC)和糖耐量正常的2型糖尿病一级亲属组( FDRs)口服75克葡萄糖后0、30、60、120、180分钟抽血，分别测定血糖、胰岛素、C肽、抑胃多肽(GIP)和胰高血糖素样肽-1(GLP-1)浓度，计算各指标曲线下面积评估其分泌情况，用 HOMA-IR、HOMA-β、ΔI30/ΔG30评估胰岛β细胞功能。结果(1)空腹血糖、胰岛素、C肽、GIP和GLP-1两组比较均无统计学差异(P>0.05)。(2)糖负荷后血糖、胰岛素、C肽、GIP、GLP-1曲线下面积两组比较均无统计学差异( P>0.05)。(3) HOMA-IR、HOMA-β、ΔI30/ΔG30两组比较均无统计学差异( P>0.05)。结论早期年轻的糖耐量正常2型糖尿病一级亲属肠促胰岛素分泌与胰岛β细胞功能可能尚未发生改变。%Objective To investigate the changes of incretin secrete and islet function in young first-degree relatives of type 2 diabetes with normal glucose tolerance. Methods The total subjects including 15 cases with normal glucose tolerance ( NC) and 15 first-degree relatives of type-2 diabetes with normal glucose tolerance ( FDRs) consumed the 75 g glucose orally. At 0, 30, 60, 120 and 180 minutes following glucose, plasma concentrations of gastric inhibitory polypeptide ( GIP ) , glucagon-like peptide-1 ( GLP-1 ) and serum concentrations of glucose, c-peptide and insulin were measured. The area under curve of evaluation index was calculated, and islet beta cell function was assessed by test HOMA-IR, HOMA-β, ΔI30/ΔG30. Results We found no significant difference in concentrations of fasting glucose, insulin, c-peptide, GIP and GLP-1 between two groups ( P>0.05) . No significant difference was observed between two groups in the areas under the curve of glucose, insulin, c-peptide, GIP and GLP-1 after 75 g oral glucose (P>0.05). No significant difference was observed in HOMA-IR, HOMA-β, ΔI30/ΔG30 between two groups ( P>0. 05 ) . Conclusions This study demonstrates that no changes of incretin and islet function in yong first-degree relatives of type 2 diabetes with normal glucose tolerance were observed.