艾司西酞普兰治疗精神分裂症后抑郁的对照研究

摘要

Objective To explore the efficacy and safety of escitalopram in the treatment of patients with post-schizophrenic depression. Methods A total of 87 patients with post-schizophrenic depression were randomly divided into study group treated with escitalopram and control group treated with citalopram for 8 weeks. They were assessed with Hamilton Depressive Scale ( HAMD) , Positive and Negative Symptoms Scales ( PANSS) and Treatment Emergent Symptom Scale (TESS) at the baseline and the 1st, 2nd, 4th, 8th weekend after treatment. Results At the 1st weekend, the score of HAMD, total score of PANSS and its negative factor score in study group were significantly lower than those at the baseline ( P < 0. 05 ) , as well as those in control group ( P < 0. 05 ). At the 8th weekend, score of HAMD, total score of PANSS and its factor scores in two groups were significantly lower than those at the baseline (P < 0.05). And the score of HAMD, total score of PANSS, negative factor score of PANSS in study group were significantly lower than those in control group ( P < 0. 05). There were no serious side effects in two groups. Conclusion In the treatment of patients with post-schizophrenic depression, escitalopram can reduce the depressive symptoms effectively and quickly with good safety.%目的:探讨艾司西酞普兰治疗精神分裂症后抑郁的疗效和安全性.方法:将87例精神分裂症后抑郁的患者随机分为研究组和对照组,分别给予艾司西酞普兰和西酞普兰系统治疗,共8周.应用汉密尔顿抑郁量表(HAMD)、阳性与阴性症状量表(PANSS)及副反应量表(TESS)于基线和治疗后1、2、4、8周末分别评定疗效和不良反应.结果:第1周末,研究组的HAMD和PANSS总分及阴性因子评分显著低于基线时(P<0.05),且其显著低于对照组的相应评分(P<0.05).第8周末,两组的HAMD和PANSS总分及各因子评分均显著低于基线(P<0.05),且研究组的HAMD和PANSS总分及阴性因子评分显著低于对照组的相应评分(P<0.05).两组患者均未出现严重不良反应.结论:艾司西酞普兰可有效、快速改善精神分裂症后抑郁患者的抑郁症状,且不良反应轻微.