Objective To explore clinical efficacy and safety of intravenous valproate and Lithium in the treatment of acute mania. Methods Forty patients with acute mania were randomized into study group (intravenous valproate combined with lithium) and control group (single lithium) for a 4 -week treatment, and were measured with BechRafaelsen mania rating scale (BRMS) and treatment emergent symptom scale (TESS) in 1st、7th、14th 、28th day of the treatment. Results There was no significant difference in efficacy between the two groups. Score of BRMS decreased significantly at the 7th day in study group, while at the 14th day in control group. The rates of efficacy and significant improvement in study group were 85％ and 55％ respectively, and in control group were 90％ and 35％ respectively.There were no significant differences in side effects between two groups. Conclusion Intravenous valproate combined with lithium is effective in the treatment of acute mania.%目的 探讨注射用丙戊酸钠联合碳酸锂治疗急性躁狂发作的疗效和安全性.方法 将40例躁狂症患者随机分配至注射用丙戊酸钠联合碳酸锂组和单用碳酸锂组,疗程为4周.用Bech-Rafaelsen躁狂量表(BRMS)在治疗前及治疗第1、7、14、28天评定疗效;用副反应量表(TESS)评定不良反应.结果 两组总体疗效相当,注射用丙戊酸钠组BRMS评分从第7天就开始显著下降,而碳酸锂组BRMS评分从第14天开始显著下降;治疗28d注射用丙戊酸钠组有效率85%,显效率55%,碳酸锂组分别为90%和35%.两组间副作用无显著性差异.结论 注射用丙戊酸钠联合锂盐治疗急性期躁狂发作疗效肯定.
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