NTRK2基因 rs1187272位点多态性与精神分裂症的首发年龄关联分析

摘要

目的：探讨中国汉族人群神经营养性酪氨酸激酶2型受体（NTRK2）基因 rs1187272位点多态性与精神分裂症首发年龄的关联性。方法选取174例精神分裂患者为研究组，其中81例为早发性精神分裂症组（早发组），93例为非早发性精神分裂症组（非早发组）；202例为正常对照（对照组）。采用 TaqMan 法，检测 NTRK2基因 rs1187272位点多态性，并使用生存分析对 rs1187272多态性与发病年龄的关联进行分析。结果（1）rs1187272等位基因及基因型分布频率在早发组与对照组之间、非早发组与对照组之间的差异有统计学意义（P ＜0．05），但在早发组与非早发组之间的差异无统计学意义（P ＞0．05）。（2）Kaplan-Meier 分析显示，研究组、早发组和非早发组危险等位基因 C 的频率与首发年龄无相关性（P ＞0．05）。结论在中国汉族人群中 NTRK2基因 rs1187272位点多态性与精神分裂症的首发年龄不相关。%Objective To investigate the association between polymorphism of rs1187272 in neurotrophic tyrosine kinase receptor type 2 (NTRK2)gene and the age of onset in schizophrenic patients.Methods Polymorphisms of rs1187272 in NTRK2 gene were genotyped by using TaqMan SNP genotyping assay in 174 schizophrenic patients (study group,consisted of 81 early-onset schizophrenics and 93 non early-onset schizophrenics)and 202 healthy controls (control group).The association between age of onset and rs1187272 polymorphism was evaluated by using survival analysis.Results (1)There were significant differences in allelic frequency and genotype frequency of rs1187272 between early-onset subgroup and control group,as well as between non early-onset subgroup and control group (P <0.05).But no significant difference was found in allelic frequency and genotype frequency between early-onset subgroup and non early-onset subgroup (P >0.05 ).(2 )Kaplan-Meier analysis indicated that the distribution of risk C allele was not significantly associated with age of onset in patients in study group,early-onset subgroup and non early-onset subgroup (P >0.05).Conclusion The polymorphism of rs1187272 in NTRK2 gene is not likely to be associated with the onset age of schizophrenia in Chinese population.