基于语言材料研究精神分裂症的存储及执行功能

摘要

Objective To investigate the verbal working memory and performing function in patients with schizophrenia.Methods A total of 40 patients with schizophrenia in study group and 40 healthy people in control group were selected and assessed with Digit Span Test(DS),N-back Paradigm Test(NPT),Positive and Negative Syndrome Scale(PANSS).Results There was no significant difference for the scores of DS between study group and control group(P ＞ 0.05).When n =1 in NPT,the correct rate in study group was significantly lower than that in control group(P ＜0.05) and the reaction time in study group was significantly longer than that in control group(P ＜ 0.05).In study group,the DS score was negatively correlated with age and duration of disorder of the patients(P ＜ 0.05).Conclusion There are obvious impairments for the verbal performing and control function in patients with schizophrenia.%目的 探讨精神分裂症对语言材料的存储及执行控制功能.方法 选取40例精神分裂症患者(患者组)及40名健康志愿者(对照组),应用数字广度测验(DS)、n-back范式测验(NPT)、阳性和阴性综合征量表(PANSS)进行评定.结果 两组DS得分比较差异无统计学意义(P＞0.05).NPT的n=1时,患者组正确率低于对照组(P＜0.05),患者组的反应时间多于对照组(P＜0.05).研究组中DS得分与年龄和病程均呈负相关(P＜0.05).结论 精神分裂症患者对语言材料的执行控制功能明显受损.