甲氨蝶呤联合米非司酮治疗异位妊娠的临床观察

摘要

Objective:To evaluate the efficacy of methotrexate combined with mifepristone in the treatment of ectopic pregnancy, and to explore new conservative treatment alternatives for ectopic pregnancy. Methods:70 cases of patients diagnosed as ectopic pregnancy in our hospital from January 2010 to December 2011 were randomly divided into two groups, the methotrexate group (control), and the methotrexate combined with mifepristone group (experimental). Results:In both groups,after 2 weeks treatment,the serum HCG level decreased significantly, and the mass average diameter significantly reduced too (P < 0. 05 and P<0. 01,respectively). The success rate of methotrexate (control) group and the methotrexate combined with mifepristone group (experimental) were 91.67% and 76.47% respectively,and the difference was significant. Conclusions:The treatment effect in the methotrexate combined with mifepristone group is better than that of methotrexate group. And there are other advantages,such as higher effective rate,lower side effects, shorter duration of therapy, and significantly reducing the economic burden of the patients. Therefore,the methotrexate combined with mifepristone treatment method is a good method to be explored.%目的:探讨甲氨蝶呤联合米非司酮治疗异位妊娠的治疗效果及安全性,为药物保守治疗异位妊娠寻找新的方法.方法:将2010年1月至2011年12月在我院确诊为异位妊娠并符合保守治疗条件的70例患者随机分为两个治疗组,以单用甲氨蝶呤治疗34例为对照组,甲氨蝶呤联合米非司酮治疗36例为研究组,观察比较两组的治疗效果.结果:两组均于治疗后2周血β-HCG明显下降,包块平均直径明显缩小,与治疗前比较差异有统计学意义(P ＜0.05,P＜0.01).研究组及对照组治愈率分别为91.67％和76.47％,两组比较差异有统计学意义(P＜0.05).研究组胃肠道反应发生率低于对照组,差异有统计学意义(P＜0.05).结论:甲氨蝶呤联合米非司酮治疗异位妊娠的效果优于单用甲氨蝶呤,且有疗效高、副反应较小的优点.