泸州市体检人群幽门螺杆菌感染状况及危险因素研究

摘要

目的 了解泸州地区健康体检人群幽门螺杆菌 (Hp) 阳性率及危险因素.方法 纳入2017年5月至2018年5月于泸州市西南医科大学附属医院、西南医科大学附属中医院、泸州市人民医院、泸县人民医院进行幽门螺杆菌感染检测健康体检人数18 684人, 如C14、C13呼气试验或Hp抗体阳性即可认为是幽门螺杆菌感染, 从中随机抽出800人行电话问卷调查, 问卷调查内容包括:一般资料、生活习惯、血型及个人和家族消化道相关既往病史.结果 泸州市体检人群Hp阳性率仅31.6％, 男性Hp阳性率32.4％ (3 788/11 836) , 女性HP阳性率为30.4％ (2 086/6 848) , 男性Hp的阳性率高于女性, 差异有统计学意义 (P=0.025) .单因素分析结果显示性别、BMI值、饮酒、饮生水、经常在外就餐、家庭成员及本人既往患过消化道疾病、既往有口腔疾病病史是幽门螺杆菌感染的危险因素, 多因素Logistic分析显示男性、BMI值、饮酒、饮生水、经常在外就餐、家庭成员及本人既往患过消化道疾病、既往有口腔疾病病史是幽门螺杆菌感染的危险因素.结论 泸州市体检人群BMI、饮生水, 在外就餐, 家庭成员及本人既往患过消化道疾病、体检本人既往有口腔疾病病史的人群是幽门螺杆菌感染的危险因素.%Objective To investigate the infection rate and risk factors of Helicobacter pylori in healthy people in Luzhou. Methods From May 2017 to May 2018, the number of physical examinations for Helicobacter pylori infection was 18, 684 in the Affiliated Hospital of Southwestern Medical University of Ganzhou, the Affiliated Hospital of Southwestern Medical University and Cangzhou People 's Hospital and Jixian People's Hospital.C14, C13 breath test or Hp antibody positive could be considered as Helicobacter pylori infection. Eight hundred people were randomly selected to conduct a telephone survey. The survey content included general information, living habits, blood type and personal and family gastrointestinal related past medical history. Results The HP infection rate of the medical examination population in Cangzhou City was 31.6％, the male HP infection rate was32.4％ (3788/11836) , the female HP infection rate was 30.4％ (2086/6848) , and the male HP infection rate was higher than that of the female (P = 0.025). Univariate analysis showed that gender, BMI, drinking, drinking water, frequent eating, family members and the previous digestive tract diseases, and previous history of oral disease were risk factors for Helicobacter pylori infection. Results of multivariate logistic analysis showed Male, BMI, drinking, drinking water, eating out often, family members and the digestive tract disease, and a history of oral disease were risk factors for Helicobacter pylori infection. Conclusion BMI, drinking water, and eating out in the medical examination population of Quzhou City, family members, the digestive tract diseases and previous history of oral disease are risk factors for Helicobacter pylori infection.