润房镜联合普拉洛芬滴眼液治疗干眼症的效果及对血清MMP-2、STRA6水平的影响

摘要

目的 分析润房镜联合普拉洛芬滴眼液治疗干眼症的效果及对血清MMP-2、STRA6水平影响.方法 选取2016年1月至2017年8月间我院收治的100例干眼病患者随机分为观察组及对照组;对照组采用普拉洛芬滴眼液治疗, 观察组采用润房镜联合普拉洛芬滴眼液治疗;治疗后对患者临床疗效进行评估, 分析治疗前后患者症状及生存质量并检测血清中MMP-2、STRA6水平.结果 观察组临床显效率显著高于对照组 (P <0.05);治疗后观察组BUT、SIt、视觉相关生存质量评分均显著高于对照组 (P <0.05);治疗后观察组症状评分、MMP-2及STRA6水平均显著低于对照组 (P <0.05) .结论 采用润房镜联合普拉洛芬滴眼液治疗干眼症后有效提高临床疗效, 减低血中MMP-2及STRA6水平.%Objective To analyze the effect of moistening room mirror combined with pranoprofen eye drops on dry eye and its effect on serum MMP-2 and STRA6 levels. Methods 100 cases with dry eye disease treated in our hospital from January 2016 to August 2017 were randomly divided into the observation group and the control group. The control and observation group were treated with pranoprofen eye drops and moisturizing room mirror combined with pranoprofen eye drops. The clinical efficacy of the patients was evaluated, and the symptoms and the survival quality, MMP-2 and STRA6 of the patients were analyzed. Results Significant clinical efficiency was significantly higher in the observation group than in the control group (P < 0.05). BUT, SIt, visual related quality of life scores in the observation group were significantly higher than the control group (P < 0.05). Symptom score, MMP-2 and STRA6 levels in the observation group were significantly lower than the control group (P < 0.05).Conclusions The combination of moisturizing chamber mirror and pralofen eye drops in the treatment of dry eye can effectively improve the clinical efficacy and reduce the levels of MMP-2 and STRA6.