小脑顶核电刺激对脑梗死患者认知功能的影响

摘要

目的:探讨小脑顶核电刺激对脑梗死患者认知功能的影响.方法:脑梗死患者270例,随机分成治疗组和对照组各135例,均接受常规药物治疗,治疗组在此基础上加用小脑顶核电刺激,于治疗前和治疗后2周、3个月、6个月进行MoCA量表、威斯康星卡片分类测验(WCST)、Stroop色词测验(SCWT)、连线测验、语词流畅性测验、数字广度分测验、符号-数字分测验评定.结果:治疗后2周,两组在各项认知测验方面均较治疗前有改善,差异有统计学意义,治疗组分数较对照组提高更明显.治疗后3个月,治疗组在连线测验、SCWT测验耗时数方面均较治疗后2周有改善,差异有统计学意义,而在其余各项认知测验分数较2周时有改善,但差异无统计学意义.对照组在各项认知测验分数方面与治疗后2周相比,均有下降,差异有统计学意义.治疗后6个月,治疗组各项认知测验与治疗后3个月相比,差异无统计学意义,而对照组在各项认知测验分数均有下降,差异有统计学意义.治疗后2周、3个月、6个月两组间各项认知测验评分比较,存在差异,治疗组的评分好于对照组.结论:电刺激小脑顶核能改善脑梗死患者的认知功能.%Objective To investigate the effect of fastigial nucleus electric stimulation on cognitive function of patients with cerebral infarction. Methods 270 patients with cerebral infarction were divided into treatment and control group, and all be treated with routine treatment. The treatment group was given fastigial nucleus electric stimulation. All the patients were evaluated with Montreal Cognitive Assessment (MoCA), Wisconsin card sorting test (WCST), Stroop color word test (SCWT), trail making test A, verbal fluency test, digit span, symbols-digital test before treatments, 2 weeks, 3 months and 6 months after treatments. Results 2 weeks after treatment, various cognitive test grades significantly improved in treatment group and control group. 3 mouths after treatment, trail making test A, SCWT time-consuming of treatment groups improved compared with 2 weeks after treatment. Compared with 2 weeks after treatment, control groups had significantly lower scores in MoCA, WCST, SCWT, trail making test A, verbal fluency test, digit span, symbols-digital test, which were statistical significance. In 6 mouths after treatment, SCWT time-consuming of treatment groups were decreased compared with 3 mouths after treatment, which was statistical significant. The rest of the cognitive tests scores were not statistical significant, however, various cognitive test grade of control groups decreased compared with 3 mouths after treatment, which were statistical significant. Conclusion Cognitive function of patients with cerebral infarction can improved by electric stimulation to cerebellar fastigial nucleus.