合肥市郊区糖耐量正常的超重人群中口服糖耐量试验1小时血糖与空腹血脂的相关性

摘要

目的：了解糖耐量正常（NGT）人群中行75 g口服葡萄糖耐量（75 g OGTT）后1 h血浆血糖（1-h PG）水平与空腹血脂谱之间的相关关系。方法：选择合肥市郊区4个社区40岁以上常住居民为研究对象，根据75 g OGTT检查结果，共筛选出6402例NGT。再依据随机数据表法随机抽取1291例NGT作为本研究对象。根据1-h PG水平，分为NGT-1组（1-h PG＜8．6 mmol／L）和NGT-2组（1-h PG≥8．6 mmol／L），两组受试者人数分别为597和694例。应用Pearson相关分析以及多元线性回归分析了解1-h PG与空腹血脂谱之间的相关关系。结果：（1） NGT-1组、NGT-2组中平均体质指数分别为24．3和24．5 kg／m2。（2）与NGT-1组相比，NGT-2组受试者的空腹血糖、OGTT 后2 h血糖、糖化血红蛋白、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-c）、TG／HDL-c、总胆固醇（TCH）／ HDL-c均显著升高（P＜0．05）。（3） Pearson相关分析以及多元线性回归分析显示，无论在NGT-1组还是NGT-2组中，1-h PG 与TG均呈正相关（P＜0．01），与HDL-c均呈负相关（P＜0．01）。结论：在NGT的超重人群中，75 g OGTT后1 h PG水平与空腹HDL-c、TG水平密切相关。%Objective To examine the association between one-hour plasma glucose (1-hPG) level during an oral glucose tolerance test (OGTT) and serum lipid profiles in individuals with NGT. Methods 6 402 individuals with NGT who underwent a 75 g OGTT were screened from four communities of Hefei suburban areas, aged over 40 years. Then 1 291 cases of NGT were randomly selected as the object of this research by random data table method. They were divided into NGT-1 group (1-h PG < 8.6 mmol/L, n = 597)and NGT-2 group(1-h PG≥8.6 mmol/L, n = 694). Pearson correlation analysis and multivariate linear regression analyses were performed to assess correlations between 1-h PG levels and lipid profiles. Results (1) The average values of body mass index were 24.3 kg/m2 in NGT-1 group, and 24.5 kg/m2 in NGT-2 group. (2) Compared with individuals in NGT-1 group , fasting plasma glucose , two-hour plasma glucose during OGTT , HbA1c , triglyceride (TG), and high-density lipoprotein-cholesterol(HDL-c) levels, TG/HDL-c ratios, and total cholesterol(TCH)/HDL-c ratios were significantly higher in individuals than in NGT-2 group. By contranst, body mass index, blood pressure , TCH and low-density lipoprotein-cholesterol levels were not significantly different between NGT-1 group and NGT-2 group. (3) The multiple linear regression analyses showed that 1 h PG levels positively correlated with TG in individuals in both NGT-1 group and NGT-2 group (P < 0.01). In addition, 1-h PG levels negatively correlated with HDL-c ratio in both groups (P < 0.01). Conclusion 1-h PG levels during OGTT in overweight individuals with NGT closely correlate with HDL-c and TG levels.