目的：探讨一种新型氧化应激标记物晚期蛋白氧化产物（AOPP）在2型糖尿病眼肌麻痹（DOMP）中的作用，为DOMP的防治提供依据。方法：分析58例DOMP和50例单纯2型糖尿病患者的临床资料，检测受试者糖化血红蛋白（HbA1c）、空腹血糖（FPG）、胰岛素（FINS）及血脂指标（TG、TC、HDL 及 LDL），采用稳态模型计算胰岛素抵抗指数（HOMA-IR）、胰岛β细胞功能（HOMA-β）及胰岛素敏感指数（ISI）。酶联免疫吸附法检测血清 AOPP 水平。建立多因素非条件二分类 Logistic 回归模型，筛选 DOMP 的独立影响因子。结果：单因素分析，DOMP组AOPP、TG、LDL、FPG、FINS、HbA1c 及HOMA-IR均高于单纯T2DM组，而HDL、HOMA-β、ISI 低于单纯T2DM组（均P ＜0．05）。 Logistic 回归分析提示，只有 AOPP 是 DOMP 的独立影响因子（OR ＝3．01， P ＝0．002）。结论：AOPP 可能参与 DOMP 的发病，可以将其作为监测 DOMP 的发生，评估DOMP程度的指标之一。%Objective To investigate the effects of advanced oxidation protein products (AOPP) in type 2 diabetic ocular muscles palsy (DOMP). Methods 58 DOMP patients and 50 type 2 diabetes patients were included in the research. Hemoglobin A1c (HbA1c), blood glucose (FPG), fasting insulin (FINS) and triglycerides (TG), total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL) were measured and recorded. Homeostasis model assessment was performed to evaluate the status of insulin resistance (HOMA-IR), basal insulin secretion (HOMA-β) and the insulin sensitivity index (ISI). Serum AOPP was measured by enzyme linked immunosorbent assay. Unconditional logistic regression model was used to evaluate the influencing factors of DOMP. Results The DOMP group showed higher levels of plasma AOPP, TG, LDL, FPG, FINS, HbA1c and HOMA-IR, but lower levels of HDL, HOMA-β and ISI than those of the T2DM group. Unconditional logistic regression analysis revealed that AOPP was an independent risk factors for DOMP (OR =3.01, P = 0.002). Conclusion AOPP may be involved in the pathogenesis of DOMP. AOPP could be a useful indicator for monitoring the development of DOMP and for evaluating its severity.
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