益气血补肝肾中药对卵巢过度刺激综合征患者血管内皮生长因子的影响

摘要

目的 观察益气血补肝肾中药对卵巢过度刺激综合征(OHSS)高危患者血管内皮生长因子(VEGF)的影响.方法 选取2016年6-11月在广州军区广州总医院生殖医学中心行试管婴儿助孕的有OHSS高危因素的患者为研究对象,随机分为中药组148例和对照组150例,另选取同期145例无OHSS高危因素的患者作为正常组.所有患者均予长方案治疗,中药组在此基础上加用中药.结果 中药组比对照组有更高的优质胚胎率及更低的中重度OHSS发生率,差异有统计学意义(P<0.05).对照组和中药组在各时间点血清VEGF水平均比正常组高(P<0.05),而中药组移植日血清VEGF水平显著低于对照组(P<0.05).结论 血清VEGF水平升高与OHSS的发生密切相关,益气血补肝肾中药可降低OHSS高危患者移植后的血清VEGF水平,对中重度OHSS的发生起到预防作用.%Objective To investigate the clinical effect of the Yiqixue Buganshen Recipe(YBR)on the level of serum VEGF in high-risk patients with OHSS. Method 298 infertile women with high-risk OHSS in the reproductive centre of our hospital from June to November ,2016 were enrolled into the traditional Chinese medicine (TCM) group (n = 148) and the control group(n = 150). 145 infertile women without high-risk OHSS were enrolled into the normal group. All the patients received the long protocol treatment ,and patients in the TCM group received the YBR treatment. Results Patients have higher quality embryo rate ,lower moderate and more severe OHSS rate in the TCM group compared with the control group(P<0.05). Patients in the normal group have lower serum VEGF compared with patients in the other 2 groups on the all three days. Patients in the TCM group has lower serum VEGF on the day of embryo transfer compared with patients in the control group(P<0.05). Conclusions The increment of the serum VEGF level is closely related to OHSS. The YBR may reduce the rate of moderate and severe OHSS by reducing the serum VEGF level on the day of embryo transfer ,which may prevent the moderate and severe OHSS of the high-risk patients.