联合检测血清抑制素A唾液酸白细胞介素-2受体和同型半胱氨酸在卵巢癌诊断中的应用

摘要

Objective To explore the early diagnostic value of combined detection of serum inhibin-A(INH-A), sialic acid (SA), interleukin-2 receptors (SIL-2R) and homocysteine (Hcy) levels in patients with ovarian cancer. Methods Serum INH-A, Hcy (with CLIA), serum SA (with biochemistry), Serum SIL-2R [with enzyme linked immunosorbent assay(ELISA)] levels were determined in 33 patients with ovarian cancer, Thirty patients with benign ovarian diseases and 35 women controls. Results The serum INH-A, SA, SIL-2R and Hcy levels and positive rate in patients with ovarian cancer were significantly higher than those in patients with benign ovarian tumor and controls (P<0.01). The positive rates of INH-A, SA, SIL-2R and Hcy levels in patients with ovarian cancer were 67%, 64%,61%, 55%, respectively. The positive rate of four markers combined detection was 88% . Conclusion INH-A could be an indicator of early ovarian which cancer screening, combined detection of ovarian cancer can significantly improve the rate of diagnose.%目的：研究联合检测血清抑制素 A（INH-A）、唾液酸（SA）、可溶性白细胞介素-2受体（SIL-2R）和同型半胱氨酸（Hcy）水平对卵巢癌的早期诊断价值。方法采用化学发光法、生化法、酶联免疫吸附试验法检测卵巢癌33例、卵巢良性疾病组30例、健康人组35例女性的血清 INH-A、SA、SIL-2R 和 Hcy 水平。结果卵巢癌组血清 INH-A、SA、SIL-2R 和 Hcy 水平均高于卵巢良性疾病组和健康人组（P<0.01）。4项标志物的阳性率分别为67%，64%，61%，55%。4项联合检测的阳性率为88%。结论 INH-A 可能成为卵巢癌早期筛查的一项指标，联合检测能明显提高卵巢癌诊断率。