血清MicroRNA作为生物学标记物对肝硬化诊断及预后判断研究进展

摘要

MicroRNA（miRNA）在生物体生长、发育及疾病发生发展等过程中都起着十分重要的作用。近期的实验表明，部分血清miRNAs在肝硬化患者水平差异较大，对肝硬化的诊断具有高度敏感性和特异性，提示血清miRNAs可作为潜在的生物学标记物用于肝硬化的临床诊断及预后判断。%MicroRNAs (miRNAs) have emerged as master regulators in several biological processes. More and more studies have shown that serum miRNAs levels differ in liver cirrhosis. Serum miRNAs may serve as a potential biomarker for dignosis and prognosis of patients with liver cirrhosis.