An 82-year-old woman presented with a more than 1 month history of two red nodules on her face. There were no signs of systemic involvement. Histopathologic examination revealed lymphoid cell infiltration in the dermis, no epidermotropic phenomenon, infiltrating cells were mainly large cells, with positive staining for CD20, CD79a, Bcl-2, MUM1 and PAX-5, Ki-67(90%), and negative staining for CD10 and Bcl-6. The diagnosis was made as primary cutaneous diffuse large B cell lymphoma-leg type on face. The patient was treated with surgical excision and systemic chemotherapy.%82岁女性患者,面部红色结节1个月余.结节组织病理示真皮内淋巴样肿瘤细胞浸润,无嗜表皮现象,细胞体积大,CD20、PAX5、CD79a、BCL-2、MUM1均阳性,Ki-67 90%阳性, BCL6、CD10阴性.诊断:面部原发性皮肤弥漫性大B细胞淋巴瘤-腿型.全身检查未发现皮肤以外系统受累证据,治疗行局部肿瘤切除及化疗.
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